Human Growth Hormone (HGH)
Human Growth Hormone (HGH)
- 1 Human Growth Hormone (HGH)
- 2 Growth Hormone in the Human Body
- 3 History of the creation and application of HGH
- 4 Modern HGH – Recombinant Growth Hormone.
- 5 HGH in sports
- 6 Pharmacological properties recombinant HGH
- 7 Main effects
- 8 Growth and strengthening of bone and cartilaginous tissue
- 9 Muscle growth, anti-catabolic properties, regulation of protein metabolism
- 10 “Burning” fats and turning them into energy
- 11 Regulation of carbohydrate metabolism
- 12 Stimulation of immunity
- 13 Improvement of cardiac activity
- 14 Acceleration of wound healing
- 15 Strengthening and healthy appearance of the skin
- 16 Endocrine cell stimulation and beneficial effects on the liver
- 17 Increased sexual activity
- 18 Indications for the use of Human Growth Hormone
- 19 Buy HGH. Human Growth Hormone for sale
Somatotropin (Human Growth Hormone) is a substance produced by the anterior pituitary gland, as well as a pharmacological drug similar to the human hormone in terms of chemical composition and properties. Somatotropin stimulates cell growth and their recovery. Due to this, it accelerates the development and growth of bones and increases their density, triggers the growth of muscles, internal organs, regulates carbohydrate metabolism, causes increased immune responses, reduces the amount of adipose tissue.
The effects of the hormone are in demand in the treatment of diseases associated with inadequate natural growth hormone production in sports. In addition, at the moment, experiments are being conducted on the use of somatotropin as a drug that slows down the aging process.
Growth Hormone in the Human Body
Generation of somatotropin in the human body, the frequency and amount of its production is formed genetically. It is known that 5 genes in the seventeenth chromosome correspond to the synthesis of the hormone. Since birth, there are 2 isoforms of somatotropin present in the human, and then several more arbitrary forms appear in the development process. This phenomenon is associated with the complication of hormonal regulation of growth processes. Each isoform in a certain way affects the nerve endings of certain organs, muscles, bones, which subsequently accelerates their growth and development.
Normally, in the pituitary gland of an adult human growth hormone is produced every three to five hours. The most powerful splash in the synthesis of HGH occurs at night, 2-2.5 hours after the onset of sleep. With age, the frequency of synthesis and the amount of the hormone decreases. Peak production is observed in early childhood, and the maximum single quantity is noted in the pubertal period (adolescence). It is natural that in an old age the intensity of development of a somatotropin is extremely low.
The movement of HGH in the body occurs through the circulatory system. Somatotropin enters the bloodstream, then interacts with the transport protein and penetrates into all organs and tissues with blood. The main effect of the hormone on receptors, located in various organs, affecting the protein target – Janus kinase. This protein activates the transport of glucose to the target cells (muscle, bone cells, epithelial cells), which leads to their growth and development.
History of the creation and application of HGH
For the first time the Growth Hormone was discovered by scientists Laius and Evans in 1920. Later in 1944, scientists managed to isolate growth hormone from the pituitary of animals. The study was of impressive scientific importance, but the resulting animal hormone was not suitable for clinical testing in humans.
In 1956, the human growth hormone was first isolated, and two years later the first successful medical use of the drug took place. In 1958, Maurice Raben, an endocrinologist from Boston, first introduced the drug to a small patient in the New England medical center. The child suffered from a disease in which the pituitary did not produce a hormone and before the appearance of the drug had no chance of recovery. The course of somatotropin caused normalization of the growth of bones and muscles, allowing the child to be cured.
In the 60-70s, the source of somatotropin was the human brain. To produce the hormone, the pituitary gland of the deceased was used. The hormone was a great rarity, since hundreds of pituitary glands were needed to receive one dose, and, accordingly, its cost was extremely high. In this case, the growth hormone could not be sterilized, since the substance is destroyed at high temperatures. Instead of sterilization, pasteurization was used. There have been cases of viral infections from the use of non-sterile growth hormone, which led to a temporary ban on its use in several countries around the world.
Modern HGH – Recombinant Growth Hormone.
In the 80 years of research in the field of genetic engineering allowed to develop a technology for the synthesis of sterile somatotropin from bacteria. After serious clinical trials, the new drug was reintroduced into clinical practice. The artificial creation of a growth hormone molecule with the exact location of amino acids was a difficult task for pharmacologists. For the first time, the technology of producing somatotropin, by cloning using the E. coli bacterium, was mastered by Genentech in 1980.
HGH produced by this company was distinguished by the presence of one more amino acid (192 instead of the 191). In clinical tests this feature did not lead to the development of additional side effects. Meanwhile, the appearance of antibodies to the drug (192 amino acids) in 30% of the subjects was noted, which did not appear clinically, but caused the alertness of some doctors and researchers. In 5% of such cases, antibodies were able to neutralize the therapeutic effect of the hormone.
In this regard, in 1981, Eli Lilly managed to develop a technology that allows producing human growth hormone completely identical to human (191 amino acids).
HGH in sports
Anabolic effects of growth hormone (accelerated muscle growth) have caused active use of somatotropin in sports. So the vast majority of bodybuilders and heavy athletes of the 80s used this drug to stimulate muscle growth and achieve high sports results. Eloquent evidence of the effectiveness and popularity of growth hormones in sports and bodybuilding has repeatedly appeared in the media, where leading athletes and their trainers talked about the high results that were achieved with the use of HGH.
In particular, the Canadian coach Charlie Francis, who was preparing the famous athlete Ben Johnson, said that his ward, like most Olympic athletes, used somatotropin in preparation for the competition. In addition, Francis confirmed that in the environment of professional bodybuilders and powerlifters, the use of growth hormone is a generally accepted and practically indispensable practice.
The active use of somatotropin in professional sports continued until the International Olympic Committee imposed a ban on the use of this substance in 1989. Despite this, in bodybuilding and a number of sports where doping control standards do not presume the detection of growth hormone, the use of the hormone continues.
The question of the relevance of the prohibition of somatotropin in preparation for competition is controversial. It is known that the use of the drug allows to achieve significant results, and there is no reliable data on the harm of such use.
In connection with the ban on the use of growth hormone in sports, at the moment in open sources there are no published studies on the effectiveness of its use in sports medicine.
Despite this, many bodybuilders and heavy departures are convinced that the effect of growth hormone protects their body from sports injuries, with a sharp increase in the working training load, which is usually necessary when using anabolic steroids. This effect is associated with the ability of the athlete to stimulate the synthesis of chondroitin, collagen, as well as the strengthening of bones, cartilage of tendons and connective tissue.
Researchers believe that the potential of growth hormone is not fully disclosed, due to the limited clinical application. The most promising are studies of the drug as a so-called. “Medicines for old age.” It is widely known the study of the British endocrinologist Daniel Redmen – “Effects of the use of somatotropin in men older than 60 years.” The scientist was able to identify such effects as a significant reduction in fat tissue, muscle mass growth, chondro and osteo-protective properties (improvement of bone and joints), appearance of mobility in the lumbar spine due to age, and a significant increase in activity.
Pharmacological properties recombinant HGH
The effects of recombinant HGH are completely analogous to the action of endogenous somatotropin.
Growth and strengthening of bone and cartilaginous tissue
One of the main effects of HGH is the effect on the receptors of bone tissue, which is manifested by linear growth of bones (In children). The most significant effect is the growth of tubular bones, i.e. extremities. The growth of flat bones is also stimulated by the hormone, but is less expressed. Similarly, the drug stimulates the growth of cartilaginous tissue.
In addition to the development of bone tissue, the Human Growth Hormone increases bone density, which in turn increases the strength of the skeleton.
A similar effect is observed with respect to the teeth. A number of effects associated with the strengthening of bone and cartilage tissue and teeth, due to the ability of the drug to enhance the absorption of calcium. In addition, thanks to the drug in the body, a large number of such essential trace elements as potassium, phosphorus, sodium and water are retained.
Muscle growth, anti-catabolic properties, regulation of protein metabolism
HGH has a powerful anabolic and anti-catabolic effect. In other words, it accelerates and increases the volume of the synthesized protein, and also reduces the rate of disintegration of protein compounds in the muscle and other tissues.
Acceleration of muscle growth is due to stimulation of protein growth and increased intensity of amino acid transport into the cell.
In this case, the drug slows down the formation of adipose tissue, while strengthening the splitting of lipids (fats). It is natural that a combination of these effects leads to an increase in the volume of muscle mass and a decrease in the volume of fatty subcutaneous deposits.
“Burning” fats and turning them into energy
As noted above, the drug accelerates lipolysis, i.e. gives the body the ability to use fatty acids from subcutaneous fat. This leads to the destruction of excess tissue fat “depot” and use them as energy. It is natural that eliminating excess fat leads to a decrease in cholesterol.
Regulation of carbohydrate metabolism
Under the influence of the Growth Hormone, there is an increase in the concentration of glucose in the blood. With respect to glucose, growth hormone is a direct insulin antagonist and acts on the carbohydrate exchange in the opposite way. Simplified, the drug allows you to save carbohydrates and increase the level of free glucose.
Stimulation of immunity
The use of the drug causes activation of the immune response, increasing resistance to infectious diseases. Immunostimulation occurs due to increased production of immunoglobulins, as well as the spread of lymphocytes and macrophages.
Improvement of cardiac activity
HGH stimulates the development of cardiomyocytes (cells of the striated muscle of the heart). This improves cardiac contractility and reduces the amount of oxygen that is necessary for the normal operation of the heart.
Acceleration of wound healing
The drug significantly accelerates the healing of burn injuries, various types of wounds, facilitates rapid recovery after surgical interventions. The effect is based on stimulating the growth of fibroblasts (cells of connective tissue) and macrophages (body cells that destroy bacteria).
Strengthening and healthy appearance of the skin
The reactions that trigger growth hormone promote the formation of collagen fibers, which in turn strengthen the skin and make it supple.
Endocrine cell stimulation and beneficial effects on the liver
An equally important effect of Growth Hormone is stimulation of growth of cells of endocrine glands. The hormone promotes the growth and renewal of cells of the thyroid and thymus glands, gonads, adrenals. The drug exhibits similar activity against liver cells – hepatocytes.
Increased sexual activity
The growth of libido is due to the stimulation of the release of sex hormones.
Indications for the use of Human Growth Hormone
Absolute indications for the use of HGH is the deficiency of endogenous somatotropin and, associated with it, the arrest of growth in children.
In medical practice, HGH can be used for:
• accelerate the healing of burns and wounds;
• treatment of nervous disorders accompanied by pituitary nazmom;
• therapy and prevention of senile dementia and other gerontological changes;
• increased bone density in degenerative lesions.
In addition, the drug can be effectively used as:
• Means to increase the volume and mass of muscles (in sports and bodybuilding);
• improve the lipid profile, as a “burner” of fat;
• Hormonal immunostimulant;
• stimulant of intellectual and physical abilities;
• a means to increase sexual activity.
Physiology and pharmacodynamics of the process
At the physiological level, the effects of HGH are due to action on the somatotropin receptors, as well as through the so-called. Protein-mediated proteins are insulin growth factor (IGF). Like the endogenous growth hormone produced by the pituitary gland, the recombinant growth hormone stimulates the production in target tissues (mostly of the liver and muscles) of the IGF, which in turn stimulates the growth of tissues and internal organs.
The effect of the drug is based on three basic reactions of the body to its introduction:
• Creation of a sufficient number of proteins, carbohydrates, fats, amino acids, minerals, by using reserve depots of the body, and delays of substances entering the body;
• direct action on organs and tissues in which there are specific receptors of somatotropin.
• stimulation of the synthesis of protein-intermediaries (growth factors).
Thus, the body receives the building material for the cells and starts the processes of their division through the hormone receptors and the action of special proteins (IGF).
It is known that the drug circulates in the blood plasma for 40-60 minutes, while its metabolic effects persist for 24-40 hours. As a result of slow adsorption of growth hormone, the peak concentration of the drug in the plasma occurs 3-5 hours after administration. The drug is excreted through the kidneys and partially the liver. According to most studies, the half-life of HGH may last approximately 2-3 hours. Due to the fact that the drug combines with transport proteins of blood, its half-life can be longer. The amount of unchanged hormone in urine is extremely difficult to measure, as it tends to zero.
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